--- title: CBC | Gotoku Chemical --- ![img_004_2](https://gotoku.cbc-pharma.com/hs-fs/hubfs/img_004_2.png?width=460&height=105&name=img_004_2.png "img_004_2") **Product Lineup** ![img_ECG-505](https://gotoku.cbc-pharma.com/hubfs/img_ECG-505.png "img_ECG-505") **E.C.G**®**-505** **Japanese Innovative disintegrant ** ECG-505 is Japanese originated disintegrant. It is widely used in the world, and CBC has been supplying ECG-505 to pharma industry globally, more than 60 countries. ECG-505 has no fear of residual solvents due to the special manufacturing method by means of water as a single solvent. [ Product Features ](https://gotoku.cbc-pharma.com#section-10) ![img_ns-300](https://gotoku.cbc-pharma.com/hubfs/img_ns-300.png "img_ns-300") **NS-300**® **Best Disintegrant for OD formulation** NS-300 is Japanese originated disintegrant in pharma industry. Due to the excellent wicking property, it exerts an effect on accelerating water-penetration into the tablets. The disintegrant absorbs water through void spaces to expand the spaces, which weakens the bonding power among particles and results in disintegration. [ Product Features ](https://gotoku.cbc-pharma.com#section-2) # CBC Group Global Network ![CBCロゴ](https://gotoku.cbc-pharma.com/hubfs/CBC%E3%83%AD%E3%82%B4.png "CBCロゴ") **Global Vendor of ECG-505 & NS-300** CBC has been collaborating with Gotoku Chemical, supplying to **more than 60 countries **stably and supporting your formulation as **exclusive global marketing agent**. Gotoku Chemical has originally developed special disintegrants for pharmaceuticals & supplements in Japan. Gotoku’s brand products, ECG-505 & NS-300 has been most widely used as useful disintegrants globally since 1961. [ Global Support ](https://gotoku.cbc-pharma.com#section-2) ## **E.C.G****®****-505 ****Characteriscs** **Product Features** ![img_001-1](https://gotoku.cbc-pharma.com/hubfs/img_001-1.png "img_001-1") **What is E.C.G®-505?** Chemical Name: **Carboxymethylcellulose Calcium **Generic Name: Carmellose Calcium (JP) CAS No. 9050-04-8 Multi Compendial: USP, EP, JP, ChP US DMF Number: 30379 Chinese DMF Number: F20180001742 Basic Application: Disintegrant Country of Origin: Japan Package: 20kgs carton box [ Inquiries ](https://gotoku.cbc-pharma.com#section-2) **Great Balanced Disintegrant** ![img_002](https://gotoku.cbc-pharma.com/hubfs/img_002.png "img_002") **E.C.G-505 has wicking power as well. ** **Good interaction with many kinds of APIs.**   ECG-505 is applicable for many kinds of API. Diabetes, Urinary, Hormone, Anti-Histamine, Anti-Virus, Anti- Parkinson, Nervous, Hypnotic sedatives, Antipyretic, Vitamin, Herbal medicine, etc. [ Inquiries ](https://gotoku.cbc-pharma.com#section-2) **Disintegration Types in Disintegrants** ![img_003](https://gotoku.cbc-pharma.com/hubfs/img_003.png "img_003") References: Pharmaceucal Technology 5163 (1984) :Pharmaceucal R & D, Vol. 12 Drug material [1]185-191P **Representative Drugs **** ****which contain E.C.G-505** ![img_005](https://gotoku.cbc-pharma.com/hubfs/img_005.jpg "img_005") ECG-505 is applicable for many kinds of API. Diabetes, Urinary, Hormone, Anti-Histamine, Anti-Virus, Anti- Parkinson, Nervous, Hypnotic sedatives, Antipyretic, Vitamin, Herbal medicine, etc. ## **NS-300 ****Characteriscs** **Product Features** ![img_006-1](https://gotoku.cbc-pharma.com/hs-fs/hubfs/img_006-1.png?width=1200&name=img_006-1.png "img_006-1") **What is NS-300?  **Chemical Name: **Carboxymethylcellulose **(＊This is **“NOT” ****Carboxymethylcellulose Sodium****.**) Generic Name: Carmellose (JP) CAS No. 9000-11-7 Multi Compendial: USP, EP, JP US DMF Number: 19767 Chinese DMF Number: F20180001743 Basic Application: Disintegrant Country of Origin: Japan Package: 20kgs carton box [ Inquiries ](https://gotoku.cbc-pharma.com#section-2) **The fundamentals of disintegration** ![img_007](https://gotoku.cbc-pharma.com/hs-fs/hubfs/img_007.png?width=1200&name=img_007.png "img_007") Among the four types of disintegration mechanisms of disintegrants, NS-300 is the wicking-type disintegrant. The disintegrant absorbs water through void spaces to expand the spaces , which weakens the bonding power among particles and results in disintegration. [ Inquiries ](https://gotoku.cbc-pharma.com#section-2) Reference :Pharmaceu cal Technology 5163 (1984) **Properes** ![img_016](https://gotoku.cbc-pharma.com/hs-fs/hubfs/img_016.jpg?width=1920&name=img_016.jpg "img_016") **NS-300 is so suitable for ODT formulation** ![img_009](https://gotoku.cbc-pharma.com/hs-fs/hubfs/img_009.png?width=1200&name=img_009.png "img_009") NS-300 has strong wicking power, therefore it is widely adopted in ODT (Oral Disintegrating Tablet) in the world. NS-300 achieves good mouth feeling & Rapid disintegration in ODT formulation. ![img_010](https://gotoku.cbc-pharma.com/hs-fs/hubfs/img_010.png?width=1200&name=img_010.png "img_010") ODT can add the value to your formulation. OD Tablet is Useful for elders & Convenient for any case. Global demand of ODT is getting high. ODT market will be USD 27billion until 2025. ![img_011](https://gotoku.cbc-pharma.com/hs-fs/hubfs/img_011.png?width=1200&name=img_011.png "img_011") OD tablet formulation should be achieved some factors, such as Rapid Disintegration, Mouth Feeling, Stability and DDS by Oral route.   NS-300 helps rapid disintegration. ## **CBC Group** ## **Global Support** **CBC Group Global Network** **Stable Supply Chain & Long History** CBC has long term experience of supplying ECG-505 & NS-300 in the world since 1961. Now we are supplying to **more than 60 countries **stably and supporting your formulation as **exclusive global marketing agent**. CBC has 43 bases and own logistics group in the world. Therefore, we can realize stable supply chain for every customers. ![img_CBCグループ](https://gotoku.cbc-pharma.com/hs-fs/hubfs/img_CBC%E3%82%B0%E3%83%AB%E3%83%BC%E3%83%97.png?width=1200&name=img_CBC%E3%82%B0%E3%83%AB%E3%83%BC%E3%83%97.png "img_CBCグループ") **CBC Group** CBC Group Bases: 43 bases in the world Head Quarter: CBC Japan (Tokyo) CBC Japan is basically controlling to supply ECG-505 & NS-300 in the world. CBC is the specialist of pharmaceutical business and we can support technical service as well. Some market are collaborating with local partners. CBC Japan’s Qualification status ISO: ISO14001 CSR Program : Ecovadis (Silver medal) **Inquiry & Sample Request** Thank you for your interest in our products. Please fill out the form below and submit it to us. Once you submit this online request form, person in charge on your request in CBC Co., Ltd. or our affiliates will contact you. **Inquiry & Sample Request** Thank you for your interest in our products. Please fill out the form below and submit it to us.Once you submit this online request form, person in charge on your request in CBC Co., Ltd. or our affiliates will contact you. [ Inquiries ](https://gotoku.cbc-pharma.com#section-2) ![Group Logo-4](https://gotoku.cbc-pharma.com/hs-fs/hubfs/Group%20Logo-4.jpg?width=200&height=89&name=Group%20Logo-4.jpg "Group Logo-4") [Company Profile](https://www.cbc.co.jp/) [Privacy policy](https://www.cbc.co.jp/privacy/)